Related Experiment Video
Updated: Aug 30, 2026

Human Egg Maturity Assessment and Its Clinical Application
Published on: August 19, 2019
Failure of oocyte maturation: possible mechanisms for oocyte maturation arrest
1ISCARE IVF, Hloubetinska 3/13, CS-198 00 Prague 9 and Institute of Animal Production, POB 1, CS-104 01 Prague 10, Czech Republic.
Abstract:
For human IVF, the patient's ovaries are hormonally stimulated to ensure the collection of fully matured oocytes that are at the metaphase II stage. Only these oocytes can be successfully fertilized either when mixed with sperm or after ICSI. Nevertheless, in some cases immature or maturing oocytes are recovered from follicles. Surprisingly, sometimes these oocytes do not complete maturation when cultured in vitro, for unknown reasons. In this article we discuss some possible mechanisms that may be responsible for those atypical arrests.
Related Concept Videos
Oogenesis
Oogenesis
Each primary oocyte is surrounded by a layer of pre-granulosa cells, forming what is known...
Meiosis II
Meiosis II
The timing and cell division patterns of meiosis differ between males and females. In male meiosis, the centrosomes are part of the formation of the meiotic spindle. However, in oocytes, including that of humans, Drosophila,...
Folliculogenesis
Nondisjunction

