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Updated: Aug 30, 2026

Assay for Adhesion and Agar Invasion in S. cerevisiae
Published on: November 8, 2006
Acivicin induce filamentous growth of Saccharomyces cerevisiae
Tsuyoshi Miyake1, Hiroyuki Sammoto, Bun-ichiro Ono
1Industrial Technology Center of Okayama Prefecture, Haga, Okayama, Japan. tsuyoshi_miyake@pref.okayama.jp
Abstract:
The antibiotic acivicin is a known inhibitor of gamma-glutamyl transpeptidase (gammaGTP). We found that acivicin can induce filamentous growth in both diploid and haploid cells of Saccharomyces cerevisiae. This phenomenon is not related to the inhibition of gammaGTP or interference in glutathione metabolism. Interestingly, yeasts used in the brewing industry are more sensitive to acivicin, suggesting that this dimorphological differentiation may be related to some characteristics of these particular strains.
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