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Altered cardiovascular responses to nitrosorbide in alcohol withdrawal
Seppo Kähkönen1, Edwin E Zvartau
1BioMag Laboratory, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland. Seppo.Kahkonen@helsinki.fi
Abstract:
The cardiovascular effects and pharmacokinetics of a single dose (20 mg sublingually) of isosorbide dinitrate (ISDN) were studied in 9 alcohol-dependent men during alcohol withdrawal syndrome (AW) on day 1 and after the resolution of AW on day 10. At the onset of AW, ISDN and its metabolites caused a hypotensive effect, which was increased on day 10, while no differences in ISDN-induced decrease in stroke volume were observed. Tachycardiac response to ISDN was more pronounced at onset of AW. On day 10, the AUC(0-1.5 h), C(max) and t((1/2)) of ISDN were increased compared with day 1. The results of this study suggest that nitric oxide may modulate the cardiovascular system in AW.
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