Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Familial acne fulminans.

S S Wong1, M H Pritchard, P J Holt

  • 1Department of Dermatology, University Hospital of Wales, Cardiff, UK.

Clinical and Experimental Dermatology
|September 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Willingness of patients to attend abdominal aortic aneurysm surveillance: The implications of COVID-19 on restarting the National Abdominal Aortic Aneurysm Screening Programme.

The British journal of surgery·2020
Same author

Comparative analysis of the outcomes of elective abdominal aortic aneurysm repair in England and Sweden.

The British journal of surgery·2018
Same author

A re-audit to evaluate the use of nutrition screening tool in the National Spinal Injuries Centre (NSIC) at Stoke Mandeville Hospital.

Clinical nutrition ESPEN·2017
Same author

Knowledge, attitudes and practices of medical staff towards obesity management in patients with spinal cord injuries: A UK, Netherland, Belgium and the Republic of Ireland survey.

Clinical nutrition ESPEN·2017
Same author

Expansion rate of descending thoracic aortic aneurysms.

The British journal of surgery·2016
Same author

Cardiovascular risk prevention and all-cause mortality in primary care patients with an abdominal aortic aneurysm.

The British journal of surgery·2016

Acne fulminans, a rare skin condition, may have a genetic component. Identical HLA phenotypes in affected siblings suggest inherited factors contribute to this rare disease.

Area of Science:

  • Dermatology
  • Genetics
  • Immunology

Background:

  • Acne fulminans is a rare, severe form of acne characterized by sudden onset of inflammatory papules, nodules, and pustules, often accompanied by systemic symptoms like arthralgia.
  • The etiology of acne fulminans remains largely unknown, with potential contributing factors including genetic predisposition and immune system dysregulation.

Observation:

  • A case of acne fulminans with arthralgia is presented in a patient whose sister experienced the same condition at the same age a decade prior.
  • Both affected siblings shared identical Human Leukocyte Antigen (HLA) phenotypes.

Findings:

  • The occurrence of acne fulminans in two siblings with identical HLA phenotypes strongly suggests a genetic susceptibility.
  • Shared HLA types indicate a potential inherited predisposition to developing acne fulminans.

Related Experiment Videos

Implications:

  • These findings highlight the potential role of genetic factors in the pathogenesis of acne fulminans.
  • Further research into the genetic underpinnings of acne fulminans could lead to improved diagnostic approaches and targeted therapies.
  • Understanding the genetic basis may also shed light on the disease's association with systemic symptoms like arthralgia.