Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Epilepsy genetics.

Dimitri M Kullmann1

  • 1Institute of Neurology, University College London, London, UK. d.kullmann@ion.ucl.ac.uk

Drugs of Today (Barcelona, Spain : 1998)
|October 31, 2003
PubMed
Summary
This summary is machine-generated.

Genetic research has identified several genes linked to idiopathic generalized epilepsy, including those causing neurodevelopmental disorders and ion channel defects. Future studies will explore their role in sporadic epilepsy cases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Next-generation chemogenetic inhibition using a brain-permeant non-prescription agent.

Signal transduction and targeted therapy·2026
Same author

UCL Queen Square Institute of Neurology: 75 years of innovation.

The Lancet. Neurology·2026
Same author

Clinical and Molecular Genetic Characterization of Landau Kleffner Syndrome: An Observational Cohort and Experimental Study.

Annals of neurology·2025
Same author

Deciphering temporal gene expression dynamics during epilepsy development using a rat model of focal neocortical epilepsy.

Epilepsia·2024
Same author

Early developmental alterations of CA1 pyramidal cells in Dravet syndrome.

Neurobiology of disease·2024
Same author

Structure-function and pharmacologic aspects of ion channels relevant to neurologic channelopathies.

Handbook of clinical neurology·2024
Same journal

Monoclonal antibodies for treatment of osteoporosis.

Drugs of today (Barcelona, Spain : 1998)·2023
Same journal

Tebentafusp: a novel drug for the treatment of metastatic uveal melanoma.

Drugs of today (Barcelona, Spain : 1998)·2023
Same journal

Sugemalimab, a novel PD-L1 inhibitor for treatment of advanced or metastatic non-small cell lung cancer.

Drugs of today (Barcelona, Spain : 1998)·2023
Same journal

Secukinumab, ixekizumab, bimekizumab and brodalumab for psoriasis and psoriatic arthritis.

Drugs of today (Barcelona, Spain : 1998)·2023
Same journal

Mitapivat for sickle cell disease and thalassemia.

Drugs of today (Barcelona, Spain : 1998)·2023
Same journal

Cenegermin for the treatment of dry eye disease.

Drugs of today (Barcelona, Spain : 1998)·2023
See all related articles

Area of Science:

  • Neurogenetics
  • Epileptology

Background:

  • Genetics are strongly suspected in idiopathic generalized epilepsy (IGE).
  • Recent discoveries include genes for Mendelian epilepsy and recessive neurodevelopmental disorders with seizures.
  • Ion channel genes have been identified in rare families with diverse IGE phenotypes.

Purpose of the Study:

  • To review the genetic discoveries in idiopathic generalized epilepsy.
  • To discuss the role of identified genes in epilepsy phenotypes.
  • To project future research directions in IGE genetics.

Main Methods:

  • Literature review of genetic studies in idiopathic generalized epilepsy.
  • Analysis of identified genes, including those for Mendelian inheritance, neurodevelopmental disorders, and ion channels.

Related Experiment Videos

  • Synthesis of findings to identify trends and future research avenues.

    • Main Results:

    • Several genes underlying epilepsy, transmitted in Mendelian fashion, have been discovered.
    • Genes causing recessive neurodevelopmental disorders with seizures are identified.
    • Ion channel genes are implicated in rare familial idiopathic epilepsy syndromes.

    Conclusions:

    • Genetic factors play a significant role in idiopathic generalized epilepsy.
    • The identified genes provide insights into epilepsy pathogenesis.
    • Further research is needed to determine the role of these genes in sporadic epilepsy.