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Related Experiment Videos

Hypopigmented mycosis fungoides.

S E Handfield-Jones1, N P Smith, S M Breathnach

  • 1St John's Dermatology Centre, St Thomas' Hospital, London, UK.

Clinical and Experimental Dermatology
|September 1, 1992
PubMed
Summary

A rare case of hypopigmented mycosis fungoides in a young Jamaican woman was documented. Early-onset, impalpable lesions responded well to PUVA therapy, indicating effective treatment for this skin lymphoma.

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Area of Science:

  • Dermatology
  • Oncology

Background:

  • Mycosis fungoides is the most common type of cutaneous T-cell lymphoma.
  • Hypopigmented mycosis fungoides presents as hypopigmented patches, often misdiagnosed.
  • Early diagnosis and treatment are crucial for managing cutaneous T-cell lymphoma.

Observation:

  • A 25-year-old Jamaican woman presented with a 10-year history of gradually developing hypopigmented patches on her arms, trunk, and limbs.
  • The lesions were clinically impalpable, posing diagnostic challenges.
  • Skin biopsy revealed atypical lymphocytes with cerebriform nuclei, consistent with mycosis fungoides.

Findings:

  • The patient was diagnosed with hypopigmented mycosis fungoides.
  • Treatment with PUVA (psoralen plus ultraviolet A) therapy resulted in complete clearance of the skin lesions.

Implications:

  • This case highlights the importance of considering mycosis fungoides in the differential diagnosis of hypopigmented patches, even in young individuals.
  • PUVA therapy can be an effective treatment option for hypopigmented mycosis fungoides.
  • Further research into the specific presentation and management of hypopigmented mycosis fungoides in diverse populations is warranted.

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