Related Experiment Videos
Acrodermatitis continua responding to cyclosporin therapy.
C C Harland1, P E Kilby, K L Dalziel
1Department of Dermatology, University Hospital, Queen's Medical Centre, Nottingham, UK.
Clinical and Experimental Dermatology
|September 1, 1992
Summary
A man with persistent acrodermatitis continua experienced widespread pustules resistant to methotrexate. Low-dose cyclosporine effectively treated this severe skin condition, inducing lasting remission.
Area of Science:
- Dermatology
- Immunology
Background:
- Acrodermatitis continua is a rare, chronic pustular dermatosis of the extremities.
- It is often recalcitrant to conventional therapies, leading to significant morbidity.
Observation:
- A 69-year-old male presented with painful, localized acrodermatitis continua.
- The condition progressed to widespread pustulation despite high-dose methotrexate treatment.
Findings:
- Low-dose cyclosporine therapy was initiated for the widespread pustular eruption.
- Cyclosporine induced a rapid and sustained remission of the acrodermatitis continua.
Implications:
- Low-dose cyclosporine represents a viable therapeutic option for severe, methotrexate-resistant acrodermatitis continua.
- This finding may guide treatment strategies for similar pustular dermatoses.