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The effects of frequency in pallidal deep brain stimulation for primary dystonia
A Kupsch1, S Klaffke, A A Kühn
1Dept. of Neurology, Charité, Campus Virchow, Humboldt University Berlin, Augustenburger Platz 1, 13353 Berlin, Germany. andreas.kupsch@charite.de
Abstract:
The effect of stimulation frequency for pallidal deep brain stimulation in five patients with either generalized or segmental dystonia was evaluated three to twelve months postoperatively via a randomized, double-blind paradigm. The quality of life and the severity of dystonic symptoms improved by approximately 60% and 43% respectively using a frequency of 130 Hz. Compared with 130 Hz a significant further clinical improvement was observed at frequencies of 180 and 250 Hz, which contrasted with a significant deterioration at lower frequencies (5, 50 Hz) compared to 130 Hz.