Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biphasic constitutive laws for biological interface evolution.

P Büchler1, D P Pioletti, L R Rakotomanana

  • 1LRO, Bat. AAB, Laboratory of Orthopedic Research, EPFL, 1015 Lausanne, Switzerland. philippe.buechler@epfl.ch

Biomechanics and Modeling in Mechanobiology
|October 31, 2003
PubMed
Summary

This study proposes a model where mechanical forces dictate tissue development at bone-implant sites. It simulates fibrous tissue growth around prostheses, focusing on micromotion stimuli.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Robotic-assisted surgery for lateral ventral hernias - experience of robot-assisted methods for retromuscular and preperitoneal abdominal wall reconstruction.

Hernia : the journal of hernias and abdominal wall surgery·2024
Same author

[Roboticassisted incisional hernia surgery-Retromuscular techniques].

Chirurgie (Heidelberg, Germany)·2023
Same author

[Robot-assisted extraperitoneal ventral hernia repair-Experience from the first 61 consecutive operations with eTEP and eTAR techniques].

Chirurgie (Heidelberg, Germany)·2022
Same author

[Current robotic ventral hernia surgery exemplified by 50 consecutive patients].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2021
Same author

Glenoid bone strain after anatomical total shoulder arthroplasty: In vitro measurements with micro-CT and digital volume correlation.

Medical engineering & physics·2020
Same author

Treatment of early onset spinal deformities with magnetically controlled growing rods: a single centre experience of 30 cases.

Journal of children's orthopaedics·2019

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Computational Biology

Background:

  • Bone-implant integration is crucial for prosthesis success.
  • Understanding tissue differentiation at the interface is key to improving implant longevity.
  • Current models lack comprehensive integration of mechanical stimuli and tissue response.

Purpose of the Study:

  • To develop a computational model for tissue differentiation at the bone-implant interface.
  • To investigate the role of mechanical environment, specifically micromotions, in tissue development.
  • To simulate the evolution of interfacial tissue around orthopedic implants.

Main Methods:

  • Formulated a hypothesis linking mechanical environment to tissue differentiation.
  • Defined equations governing interfacial tissue evolution.

Related Experiment Videos

  • Integrated these equations with a finite element analysis (FEA) code.
  • Applied the model to an idealized hip prosthesis scenario.

    • Main Results:

    • The model predicts tissue differentiation based on mechanical stimuli.
    • Micromotions were identified as a significant stimulus influencing tissue evolution.
    • Simulations demonstrated the development of fibrous tissue around the idealized prosthesis.

    Conclusions:

    • Mechanical environment, particularly micromotions, plays a critical role in bone-implant interface tissue differentiation.
    • The proposed model provides a framework for predicting interfacial tissue evolution.
    • This approach can aid in the design and optimization of orthopedic implants.