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Glomerulonephritis induced by methicillin-sensitive Staphylococcus aureus infection.
Tomohiro Handa1, Takahiko Ono, Hitomi Watanabe
1Division of Nephrology, Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawaracho, Sakyo-ku, Kyoto 606-8507, Japan.
Clinical and Experimental Nephrology
|October 31, 2003
Summary
Methicillin-sensitive Staphylococcus aureus (MSSA) can cause IgA nephropathy and glomerulonephritis. Antibiotic treatment resolved the condition, suggesting MSSA as a potential trigger for this kidney disease.
Area of Science:
- Nephrology
- Infectious Diseases
- Immunology
Background:
- Glomerulonephritis, particularly IgA nephropathy, can be triggered by bacterial infections.
- Methicillin-resistant Staphylococcus aureus (MRSA) is a known cause of glomerulonephritis via superantigen T-cell stimulation.
Observation:
- A 57-year-old woman presented with atopic dermatitis exacerbation, fever, nephrotic syndrome, and microscopic hematuria.
- Bacteriological studies identified methicillin-sensitive Staphylococcus aureus (MSSA) in pharyngeal mucus, stool, and blood samples.
- Renal biopsy revealed endocapillary proliferative glomerulonephritis with significant IgA deposition.
Findings:
- Antistaphylococcal antibiotic therapy led to MSSA clearance and decreased urinary protein levels.
- A follow-up renal biopsy showed resolution of glomerulonephritis and IgA deposition.
- These findings suggest MSSA, similar to MRSA, can induce glomerulonephritis.
Implications:
- This case broadens the understanding of Staphylococcus aureus-related glomerulonephritis.
- It highlights MSSA as a potential pathogen causing IgA nephropathy.
- Effective antibiotic treatment can lead to renal recovery in MSSA-induced glomerulonephritis.