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Scope of worldwide hepatitis C problem
Robert S Brown1, Paul J Gaglio
1Department of Medicine, Columbia University College of Physicians & Surgeons, and Center for Liver Disease and Transplantation, New York-Presbyterian Hospital, New York, NY 10032, USA. rb464@columbia.edu
Summary
Hepatitis C affects over 170 million globally, primarily spreading through blood. Despite declining new cases, the disease burden is projected to rise, impacting mortality and healthcare costs.
Area of Science:
- Hepatology
- Infectious Diseases
- Public Health
Background:
- Hepatitis C virus (HCV) poses a significant global health challenge, impacting over 170 million individuals worldwide.
- Geographic variations in HCV prevalence and genotype distribution are notable.
- HCV is a primary cause of liver disease and liver cancer.
Purpose of the Study:
- To summarize the global impact and transmission of Hepatitis C.
- To highlight the increasing disease burden despite declining incidence.
Main Methods:
- Review of global epidemiological data on Hepatitis C.
- Analysis of transmission routes and disease outcomes.
Main Results:
- Hepatitis C affects over 170 million people globally with significant geographic variations.
- Parenteral transmission, including intravenous drug use and contaminated medical procedures, is the primary route of spread.
- Hepatitis C is a leading cause of end-stage liver disease and hepatocellular carcinoma.
Conclusions:
- The incidence of new Hepatitis C infections is declining.
- The overall disease burden, including mortality and economic costs, is expected to increase over the next decade.