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Accuracy and reproducibility in phase contrast imaging using SENSE.

Per Thunberg1, Matts Karlsson, Lars Wigström

  • 1Department of Biomedical Engineering, Orebro University Hospital, Orebro, Sweden. per.thunberg@orebroll.se

Magnetic Resonance in Medicine
|October 31, 2003
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Summary

This study evaluated phase contrast imaging with sensitivity encoding (SENSE) at various reduction factors. Accurate flow measurements are achievable even at high reduction factors by considering the geometry factor.

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Area of Science:

  • Medical Imaging
  • Biomedical Engineering
  • Cardiovascular Imaging

Background:

  • Phase contrast imaging is crucial for quantifying blood flow.
  • Sensitivity encoding (SENSE) accelerates MRI acquisition but can impact image quality.
  • Understanding SENSE's effect on accuracy and reproducibility is vital for reliable flow measurements.

Purpose of the Study:

  • To evaluate the accuracy and reproducibility of phase contrast imaging using SENSE at different reduction factors.
  • To derive analytical expressions for reproducibility in velocity and flow measurements.
  • To validate these expressions and assess accuracy impacts through simulations and experimental studies.

Main Methods:

  • Derivation of analytical expressions for reproducibility.
  • Computer simulations to model SENSE effects.
  • In vitro and in vivo studies to validate expressions and assess accuracy.
  • Analysis of the influence of reduction and geometry factors on measurements.

Main Results:

  • Reproducibility is dependent on reduction and geometry factors, varying spatially.
  • High geometry factors can lead to increased standard deviation (SD) and aliasing.
  • SENSE does not directly affect accuracy but can indirectly impact it via increased SD and aliasing.
  • Accurate flow measurements are possible even at high reduction factors.

Conclusions:

  • Phase contrast imaging with SENSE can achieve accurate flow measurements at high reduction factors.
  • Accounting for the geometry factor is key to identifying regions of accurate imaging.
  • This understanding can optimize SENSE-based phase contrast imaging protocols for clinical use.