Related Experiment Video

Updated: Aug 30, 2026

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
11:43

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

Published on: April 3, 2015

Membrane-type 1 matrix metalloproteinase and cell migration

Motoharu Seiki1, Hidetoshi Mori, Masahiro Kajita

  • 1Division of Cancer Cell Research, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokane-dai, Minato-ku, Tokyo 108-8639, Japan. mseiki@ims.u-tokyo.ac.jp

Biochemical Society Symposium
|November 1, 2003
PubMed

Insights

Membrane-type 1 matrix metalloproteinase (MT1-MMP) regulates cell migration by degrading extracellular matrix. Understanding MT1-MMP regulation is key to controlling cell movement in various biological processes.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Background:

  • Membrane-type 1 matrix metalloproteinase (MT1-MMP) is crucial for processing cell surface proteins and degrading extracellular matrix (ECM).
  • MT1-MMP regulates critical cellular functions like migration, invasion, and morphogenesis.
  • Strict transcriptional and post-translational regulation of MT1-MMP is essential for its functions.

Purpose of the Study:

  • To summarize recent findings on MT1-MMP regulation during cell migration.
  • To elucidate how MT1-MMP controls cell migration.

Main Methods:

  • The study summarizes existing research and findings on MT1-MMP regulation and function.
  • Focuses on transcriptional and post-translational regulatory mechanisms.
  • Examines the role of MT1-MMP in cell migration and invasion.

Main Results:

  • MT1-MMP is identified as an invasion-promoting enzyme in malignant cells.
  • MT1-MMP activates proMMP-2, contributing to basement membrane invasion.
  • MT1-MMP promotes cancer cell invasion and angiogenesis.

Conclusions:

  • MT1-MMP plays a significant role in cancer cell invasion and angiogenesis.
  • Further research is needed to fully understand MT1-MMP's complex regulatory mechanisms.
  • MT1-MMP's involvement in cell migration highlights its importance in various physiological and pathological processes.

More Related Videos

Measuring Global Cellular Matrix Metalloproteinase and Metabolic Activity in 3D Hydrogels07:39

Measuring Global Cellular Matrix Metalloproteinase and Metabolic Activity in 3D Hydrogels

Published on: January 22, 2019

Related Concept Videos

Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult body.
A...
Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However, invadopodia can...
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction. It is...