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Mortality variables in pyogenic meningitis in paediatric age group
Ghulam Qasim Khichi1, Muhammad Saleem Channar, Muhammad Arshad Mannan
1Department of Paediatrics, Unit-II, Quaid-e-Azam Medical College, Bahawalpur. qasimkhichi@yahoo.com
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|November 1, 2003
Summary
Mortality in pediatric pyogenic meningitis is linked to prolonged illness duration and cerebrospinal fluid (CSF) neutrophilia. Early recognition and prompt treatment can reduce pyogenic meningitis mortality rates.
Area of Science:
- Pediatric Infectious Diseases
- Clinical Neurology
- Microbiology
Background:
- Pyogenic meningitis poses a significant threat to children, with variable mortality rates.
- Identifying factors associated with mortality is crucial for improving patient outcomes.
Purpose of the Study:
- To investigate the association of various clinical and laboratory variables with mortality in pediatric pyogenic meningitis.
Main Methods:
- An observational analytical study was conducted on 300 pediatric patients diagnosed with pyogenic meningitis.
- Data on illness duration, cerebrospinal fluid (CSF) analysis, and causative microorganisms were collected and analyzed.
- Statistical significance was determined using the Chi-squared (X2) test, with p<0.05 considered significant.
Main Results:
- The overall mortality rate for pyogenic meningitis in this cohort was 10% (30/300).
- Prolonged illness duration before admission and elevated CSF neutrophils were significantly associated with increased mortality.
- Streptococcus pneumoniae was the only etiological microorganism with a statistically significant association with mortality.
Conclusions:
- Mortality in pediatric pyogenic meningitis is significantly associated with pre-admission illness duration and CSF neutrophilia.
- Prompt recognition, early initiation of antibiotic and supportive therapy, and targeted treatment based on CSF culture results are essential for reducing mortality.