Longitudinal neuropsychological effects of n-hexane exposure: neurotoxic effects versus depression

Human exposure to n-hexane (a hexacarbon solvent) is relatively frequent as it is used in many industries as a solvent, a thinner, and a cleaning agent. This report examines a case of peak n-hexane exposure, involving known exposure to high levels over a relatively brief period of time. Peak exposure is a risk factor for persisting neuropsychological impairment. However, cognitive deficits and depression have not been measured in studies of n-hexane, and only peripheral neuropathy, often reversible, is thought to be the neurological risk. This case demonstrates the longitudinal patterns of neuropsychological functions and emotion, and represents the early and late developing effects of n-hexane exposure that parallel the longitudinal change reported in groups of workers with solvent exposure.