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Related Experiment Videos

[Intracerebral gliofibroma].

J R Iglesias-Rozas1, B Kraus-Huonder, R Michilli

  • 1Pathologisches Institut, Katharinenhospital, Stuttgart.

Deutsche Medizinische Wochenschrift (1946)
|December 11, 1992
PubMed
Summary
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A rare gliofibroma, a brain tumor with astrocytes and fibroblasts, was successfully removed from a 14-month-old girl. Complete resection led to no recurrence, indicating a favorable prognosis for this type of pediatric brain tumor.

Area of Science:

  • Pediatric Neurosurgery
  • Neuro-oncology
  • Histopathology

Background:

  • Epileptiform seizures in infants can indicate underlying neurological pathology.
  • Intracerebral tumors are a significant cause of neurological deficits in children.
  • Accurate tumor classification is crucial for determining prognosis and treatment strategies.

Observation:

  • A 14-month-old girl presented with recurrent focal seizures characterized by right arm and hand movements, followed by transient weakness.
  • Neuroimaging revealed a large left frontoparietal intracerebral tumor with cystic components.
  • Surgical exploration identified a non-encapsulated, non-infiltrating tumor measuring 7 cm in diameter.

Findings:

  • Complete surgical resection of the intracerebral tumor was achieved.

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  • Histopathological and immunohistochemical analysis confirmed the tumor as a gliofibroma, comprising interwoven astrocytes and fibroblasts.
  • No evidence of tumor recurrence was observed 18 months post-surgery.

    • Implications:

    • Gliofibromas, a rare glial-fibroblastic tumor, demonstrate a favorable prognosis following complete resection in pediatric cases.
    • Accurate immunohistochemical analysis is vital for distinguishing gliofibromas from pure glial tumors, which have a poorer prognosis.
    • This case highlights the importance of thorough histopathological evaluation for guiding therapeutic decisions and predicting outcomes in pediatric brain tumors.