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Measuring personality and emotional functioning in multiple sclerosis: a cautionary note.

Linda D Nelson¹, Joseph T Elder, Pany Tehrani

¹Neurology Department, University of California, Irvine, Medical Center, 101 The City Drive, Route 81, Building 53, Room 225, Orange, CA 92868, USA. ldnelson@uci.edu

Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists

|November 1, 2003

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Personality changes in multiple sclerosis (MS) can be clarified. A statistical correction for the MMPI-2 test removed physical symptoms, significantly lowering scores on eight clinical scales.

Area of Science:

Psychological assessment
Neuropsychology
Clinical psychology

Background:

Individuals with multiple sclerosis (MS) frequently experience alterations in personality and emotional state.
The Minnesota Multiphasic Personality Inventory-2 (MMPI-2) is a widely used psychological assessment tool.
Physical symptoms in MS can potentially confound MMPI-2 results.

Purpose of the Study:

To evaluate MMPI-2 scores in multiple sclerosis patients before and after applying a statistical correction procedure.
To determine the impact of removing items related to physical symptoms on MMPI-2 scale scores.
To assess the stability of MMPI-2 scores over a one-year period in MS patients.

Main Methods:

Twenty-eight participants diagnosed with multiple sclerosis (MS) were administered the MMPI-2.

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Participants were retested using the MMPI-2 one year after the initial assessment.

A statistical correction procedure (Gass, 1992) was applied to identify and remove items related to physical symptoms from the MMPI-2 data.

Main Results:

MMPI-2 scores demonstrated stability over the one-year retest interval.
Application of the statistical correction procedure resulted in an average decrease of 6.66 T-score points on eight standard clinical scales.
Significant differences were observed between standard and corrected MMPI-2 profiles on Scales 1, 2, 3, and 8.

Conclusions:

The statistical correction procedure significantly alters MMPI-2 profiles in individuals with MS by accounting for physical symptoms.
MMPI-2 interpretation for neurological samples, particularly MS patients, requires cautious consideration due to potential symptom-related confounds.
This study validates a more reliable method for deriving T-scores in the correction procedure for MS populations.