Clinical prediction of periodic leg movements during sleep in children

To assess the utility of several symptoms and a questionnaire-based scale in the identification of children with periodic leg movements during sleep (PLMS).

PLMS may have important consequences in some children, but the extent to which a diagnosis can be established by clinical history is unknown.

Subjects were patients aged 2-18 years who underwent polysomnography to assess for sleep-disordered breathing (SDB). Parents completed a Pediatric Sleep Questionnaire which contained items under consideration for inclusion in the desired scale.

Subjects (n=113) had a mean age of 9.8+/-4.0 (SD) and 73 (65%) were male; 59 (52%) had SDB and 29 (26%) had five or more PLMS per hour of sleep (PLMI> or =5). Severity of SDB was not different among those with and without PLMI> or =5. Yes/no responses to several question-items--about restless legs, growing pains, leaving the bed at night, waking more than twice per night, waking feeling unrefreshed, and morning headaches--showed some association with PLMI> or =5 and were combined into a composite PLMS score artificially weighted toward the first two items. The PLMS score averaged 0.40+/-0.31 and ranged from 0.0 to 1.0; a 1 SD increase was associated with PLMI> or =5 (odds ratio=1.87, 95% confidence interval (1.15, 3.13), P=0.014) after adjustment for age, sex, and SDB severity. Sensitivity of a PLMS score>0.33 for PLMI> or =5 was 0.79, specificity was 0.56, positive predictive value was 0.38, and negative predictive value was 0.89. Internal consistency was reasonable (Cronbach's alpha=0.71), as was test-retest reliability (rho=0.62, P=0.0026, n=21 separate subjects).

Restless legs, growing pains, sleep-maintenance insomnia, unrefreshing sleep, and morning headaches show moderate associations with polysomnographically-defined PLMS, but several other symptoms do not. These results require confirmation but suggest that clinical assessment and the PLMS score may be helpful but far from definitive.