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Related Experiment Videos

Hypercoagulability in patients with obstructive sleep apnea.

J J Guardiola1, P J Matheson, L C Clavijo

  • 1Division of Respiratory, Critical Care and Environmental Medicine, University of Louisville, School of Medicine and Veterans Affairs Medical Center, KY, USA.

Sleep Medicine
|November 1, 2003
PubMed
Summary

Obstructive sleep apnea (OSA) is linked to hypercoagulability, increasing cardiovascular risks. Chronic nasal continuous positive airway pressure (NCPAP) treatment appears to reverse this blood clotting tendency in OSA patients.

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Area of Science:

  • Cardiovascular Medicine
  • Sleep Medicine
  • Hematology

Background:

  • Obstructive sleep apnea (OSA) is associated with increased cardiovascular risks, including stroke and myocardial infarction.
  • Previous research indicates elevated fibrinogen and platelet aggregation in OSA patients, which resolve with nasal continuous positive airway pressure (NCPAP) treatment.
  • The overall coagulability in OSA patients requires further investigation.

Purpose of the Study:

  • To examine whole blood coagulability in OSA patients.
  • To compare coagulability between chronically NCPAP-treated OSA subjects, untreated OSA subjects, and OSA subjects after one night of NCPAP treatment.

Main Methods:

  • Whole blood coagulability was assessed in three groups: 11 chronically NCPAP-treated OSA subjects, 22 untreated OSA subjects, and 16 of the untreated subjects after one night of NCPAP.

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  • Blood samples were collected during polysomnography prior to bedtime (21:00 h) and upon waking (07:00 h).

    • Main Results:

    • Untreated OSA patients exhibited significantly faster P.M. clotting times compared to chronically treated OSA patients (3.33±0.31 min vs. 6.12±0.66 min, P<0.05).
    • Similar significant differences were observed in A.M. clotting times between untreated and chronically treated OSA patients (4.31±0.34 min vs. 7.08±0.52 min, P<0.05).
    • One overnight NCPAP treatment did not significantly alter A.M. whole blood coagulability in 16 subjects (4.35±0.43 min to 5.31±0.53 min, P=0.1).

    Conclusions:

    • Data suggest a link between obstructive sleep apnea and a hypercoagulable state.
    • Chronic NCPAP treatment appears to reverse this hypercoagulability in OSA patients.
    • NCPAP therapy may offer protection against cardiovascular complications in individuals with OSA.