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Chromogranin A processing in sympathetic neurons and release of chromogranin A fragments from sheep spleen
B Miserez1, W Annaert, L Dillen
1Department of Medicine, University of Antwerp (UIA), Wilrijk, Belgium.
FEBS Letters
|December 14, 1992
Abstract:
Chromogranin A (CGA) has been localized to the large dense cored vesicles (LDV) of sympathetic neurons. SDS-PAGE and immunoblotting of soluble LDV proteins from ox and dog adrenergic neuronal cell bodies, axons and nerve terminals, revealed an increasing number of CGA-immunoreactive forms, consistent with proteolytic processing during axonal transport. Splenic nerve electrical stimulation (10 Hz, 2 min) revealed that, apart from CGA, these CGA-processing products are released from the sheep spleen. The secretion of CGA-derived fragments from sympathetic neurons might suggest a role in the regulation of synaptic transmission.