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Triethylene tetraamine: a novel telomerase inhibitor
Fei Yin1, Jianhui Liu, Xiaojun Peng
1State Key Laboratory of Fine Chemicals, Dalian University of Technology, 158 Zhong-shan Road, 116012 Dalian, P.R. China.
Bioorganic & Medicinal Chemistry Letters
|November 1, 2003
Abstract:
Telomerase inhibition can be achieved by stabilization of G-quadruplex structure. Triethylene tetraamine, a small linear molecule, has been identified as a potent telomerase inhibitor. It stabilizes both intra- and inter-molecular G-quadruplexes and shows a good differential between potent telomerase inhibition and acute cytotoxicity.