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Updated: Aug 30, 2026

On-Chip Endothelial Inflammatory Phenotyping
Published on: July 21, 2012
11,12-epoxyeicosatrienoic acid (11,12-EET): structural determinants for inhibition of TNF-alpha-induced VCAM-1
J R Falck1, L Manmohan Reddy, Y Krishna Reddy
1Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9038, USA. j.falck@utsouthwestern.edu
Abstract:
A series of 11,12-EET analogues were synthesized and compared using a human endothelial cell based TNF-alpha-induced VCAM-1 expression assay. The resulting data were used to map a putative recognition/binding domain for 11,12-EET.
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