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The chemokine receptor, CCR5.
Anja Mueller1, Philip G Strange
1School of Animal and Microbial Sciences, University of Reading, P.O. Box 228, Whiteknights, RG6 6AJ, Reading RG6 6AJ, UK.
The International Journal of Biochemistry & Cell Biology
|November 1, 2003
Summary
The chemokine receptor CCR5 is crucial for HIV-1 entry into cells. Understanding CCR5 regulation is key to controlling HIV-1 infection rates.
Area of Science:
- Immunology
- Virology
- Cell Biology
Background:
- The chemokine receptor CCR5 (C-C chemokine receptor type 5) is a G protein-coupled receptor.
- CCR5 mediates cellular responses to chemokines CCL3, CCL4, and CCL5.
- CCR5 serves as a critical co-receptor for the entry of human immunodeficiency virus-1 (HIV-1) into host cells.
Purpose of the Study:
- To investigate the role of CCR5 in HIV-1 infection.
- To highlight the importance of CCR5 regulation in controlling HIV-1 infectivity.
Main Methods:
- This study focuses on the known functions and implications of CCR5.
- Literature review and analysis of existing data on CCR5 and HIV-1 interactions.
Main Results:
- CCR5's function as a co-receptor for HIV-1 entry is confirmed.
- The number of CCR5 receptors on cell surfaces directly influences HIV-1 infection rates.
Conclusions:
- CCR5 plays a pivotal role in the pathogenesis of HIV-1.
- Targeting CCR5 expression or function presents a potential strategy for managing HIV-1 infection.