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Effect of hyperprolactinemia on the androgen response to an oral glucose load
T Falcone1, S Meltzer, D Morris
1Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
Objective:
To investigate the effect of hyperprolactinemia on the androgen response to an oral glucose load in patients with normal and abnormal carbohydrate metabolism.
Design:
Sixty-three women underwent a 75-g oral glucose tolerance test (OGTT) at approximately 6 weeks' postpartum.
Setting:
University hospital setting.
Patients:
Patients with a previous history of gestational diabetes.
Main Outcome Measure:
Adrenal and ovarian androgen response to oral glucose load.
Results:
Results were stratified by the result of the OGTT (patients with impaired glucose tolerance or diabetes as a single group and patients with a normal OGTT as a separate group) and prolactin (PRL) level. All androgens decreased significantly over the 2-hour test in all groups except dehydroepiandrosterone sulfate (DHEAS) in the patients with both elevated PRL and abnormal glucose tolerance.
Conclusion:
Hyperprolactinemia and insulin resistance may act synergistically in the adrenal to alter DHEAS suppression and may result in chronically elevated circulating DHEAS levels.