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TNF-alpha and TNF-beta gene polymorphisms in cerebral infarction
Jae-Young Um1, Neeon-Hyung An, Hyung-Min Kim
1Department of Pharmacology, College of Oriental Medicine, Kyung Hee University, Dongdaemun-Gu, Seoul 130-701, South Korea.
Journal of Molecular Neuroscience : MN
|November 1, 2003
Summary
Genetic variations in Tumor Necrosis Factor-alpha (TNF-alpha) and TNF-beta genes are linked to cerebral infarction (CI) risk. Specific TNF-alpha genotypes may offer resistance, while TNF-beta genotypes increase susceptibility to CI.
Area of Science:
- Genetics
- Immunology
- Neurology
Background:
- Tumor Necrosis Factor (TNF) is a key cytokine in atherosclerosis inflammation.
- Genetic polymorphisms in TNF-alpha and TNF-beta influence TNF production and inflammatory disease susceptibility.
Purpose of the Study:
- To investigate the association between TNF-alpha (-308 G-->A) and TNF-beta (+252 A-->G) gene polymorphisms and cerebral infarction (CI) risk.
Main Methods:
- Case-control study involving 294 CI survivors and 581 matched controls.
- Genotyping analysis for TNF-alpha -308 and TNF-beta +252 polymorphisms.
Main Results:
- Significant associations found between TNF genotypes and CI.
- TNF-alpha A allele was more prevalent in controls, suggesting a protective role.
- TNF-beta AA genotype was increased in CI patients, indicating susceptibility.
- TNF-alpha GG genotype elevated CI risk in subjects with TNF-beta AA genotype.
Conclusions:
- The TNF-alpha -308 and TNF-beta +252 loci are implicated in the etiopathogenesis of cerebral infarction.
- Specific TNF gene polymorphisms may influence individual susceptibility or resistance to CI.