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Related Experiment Videos

Post-menopausal cyclic eruptions: autoimmune progesterone dermatitis.

I I Bolaji1, E M O'Dwyer

  • 1Department of Obstetrics and Gynaecology, University College Hospital, Galway, Ireland.

European Journal of Obstetrics, Gynecology, and Reproductive Biology
|November 19, 1992
PubMed
Summary

Autoimmune progesterone dermatitis (AIPD) can cause recurrent skin eruptions after hormone therapy. Diagnosis involves intradermal testing, with treatment typically including prednisolone.

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Area of Science:

  • Dermatology
  • Endocrinology
  • Immunology

Background:

  • Hormone replacement therapy (HRT) is commonly used for menopausal symptoms.
  • Adverse skin reactions to HRT are rare but can occur.
  • Autoimmune progesterone dermatitis (AIPD) is an uncommon condition linked to progesterone exposure.

Observation:

  • Two patients presented with recurrent, primarily extremity-based skin eruptions.
  • Symptoms appeared after initiating oral estrogen/progesterone replacement for climacteric symptoms.
  • One patient showed a positive intradermal progesterone injection test, confirming the diagnosis.

Findings:

  • Autoimmune progesterone dermatitis (AIPD) is characterized by hypersensitivity to progesterone.
  • Diagnosis can be confirmed via intradermal progesterone challenge.

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  • Transient corticosteroid therapy (prednisolone) was effective in managing symptoms.

    • Implications:

    • Highlights the importance of considering AIPD in patients with dermatological reactions to HRT.
    • Suggests potential diagnostic and therapeutic strategies for AIPD.
    • Further research into the immunological mechanisms underlying AIPD is warranted.