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Published on: April 7, 2015

[Relationship between Chlamydia pneumoniae and classical risk factors of coronary heart disease]

A Sh Khasaev1, Z G Gadzhieva

  • 1Dagestan State Medical Academy, pl. V.I. Lenina 1, 367012 Makhachkala, Russia.

Kardiologiia
|November 1, 2003
PubMed

Insights

Chlamydia pneumoniae infection, indicated by IgA antibodies, is linked to coronary heart disease and its risk factors like high cholesterol and smoking.

Area of Science:

  • Infectious Disease Epidemiology
  • Cardiovascular Medicine

Background:

  • Chlamydia pneumoniae infection is a potential contributor to cardiovascular disease.
  • Established risk factors for coronary heart disease include hypercholesterolemia, hyperglycemia, hyperfibrinogenemia, smoking, and age.

Purpose of the Study:

  • To investigate the association between Chlamydia pneumoniae infection and coronary heart disease risk factors.
  • To determine the presence of chlamydial antibodies in patients with ischemic heart disease.

Main Methods:

  • Solid phase enzyme immunoassay was used to measure IgA and IgG antibodies against Chlamydia pneumoniae.
  • 122 patients with ischemic heart disease and 40 healthy controls were analyzed.

Main Results:

  • Elevated IgA antibody titers were significantly associated with ischemic heart disease.
  • Chlamydia pneumoniae IgA antibodies correlated with hypercholesterolemia, hyperglycemia, hyperfibrinogenemia, and smoking.

Conclusions:

  • Chlamydia pneumoniae infection may play a role in the development of ischemic heart disease.
  • The presence of Chlamydia pneumoniae IgA antibodies is linked to key cardiovascular risk factors.

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