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Updated: Aug 30, 2026
Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease
Published on: May 22, 2026
[Longitudinal global and regional left ventricular function in patients with hypertensive disease (tissue Doppler
E N Pavliukova1, O V Guseva, V V Poddubnyĭ
1Research Institute for Cardiology of the Reseacrh Centre of RAMS Sibetian Branch; ul. Kievskaya 111, 634012 Tomsk, Russia.
Insights
Impulse tissue Doppler study reveals that hypertension impairs left ventricular function, even with normal transmitral flow. This method is crucial for detecting diastolic dysfunction in hypertensive patients.
Area of Science:
- Cardiology
- Medical Imaging
- Physiology
Background:
- Hypertension is a major risk factor for cardiovascular disease.
- Left ventricular geometry changes are common in hypertension.
- Early detection of diastolic dysfunction is crucial for managing hypertensive heart disease.
Purpose of the Study:
- To evaluate the utility of impulse tissue Doppler study in assessing left ventricular diastolic function in hypertensive patients.
- To compare diastolic function parameters between hypertensive patients and healthy controls.
- To identify correlations between left ventricular geometry and diastolic dysfunction in hypertension.
Main Methods:
- Impulse tissue Doppler imaging was performed on 154 hypertensive patients and 39 healthy volunteers.
- Left ventricular geometry was classified into normal, concentric remodeling, concentric hypertrophy, and eccentric hypertrophy.
- Tissue Doppler spectra were analyzed from the mitral annulus and 15 left ventricular segments to obtain diastolic function parameters.
Main Results:
- Hypertensive patients exhibited reduced longitudinal global systolic function compared to controls.
- Concentric left ventricular hypertrophy was associated with the most severe diastolic dysfunction.
- Segmental diastolic dysfunction was detected in hypertensive patients even with normal transmitral flow and normal left ventricular geometry.
Conclusions:
- Impulse tissue Doppler study is valuable for assessing longitudinal segmental diastolic function in hypertensive patients, especially those with normal transmitral flow.
- The study highlights the prevalence of diastolic dysfunction in various stages of hypertensive heart disease.
- Tissue Doppler imaging aids in the early identification of subclinical diastolic abnormalities in hypertension.
Abstract:
Impulse tissue doppler study was carried out in 154 patients with hypertensive disease (age 35-60 years) and 39 practically healthy volunteers (mean age 43.4+/-5.5 years). According to left ventricular geometry the following groups of patients were distinguished (after A.Ganau): with normal geometry (n=47), with concentric remodeling (n=12), with concentric hypertrophy (n=53), and with eccentric hypertrophy (n=42). Tissue doppler spectrum was registered from mitral annulus and 15 left ventricular segments. The following characteristics were obtained: in each annular spectrum - maximal velocities of peaks s(m), e(m), a(m), ratio e(m)/a(m), isovolumic relaxation time (ivrt) and their average values (from 6 measurements); in each left ventricular segmental spectrum - maximal velocities of waves s, e, a, ratio e/a and segmental ivrt. Compared with healthy persons patients with hypertension had lowered longitudinal global systolic function of the left ventricle. Patients with concentric left ventricular hypertrophy had least values of e(m), e(m)/a(m), ivrt(m) and greatest number of dysfunctional (e/a<1.0 and ivrt>90 ms) segments. Some hypertensive patients with normal values of transmitral blood flow had signs of segmental diastolic dysfunction. Among patients with normal left ventricular geometry isolated segmental diastolic dysfunction was revealed according to e/a in 12 of 20 (60%), according to ivrt in 11 of 22 (50%). All patients with concentric and eccentric left ventricular hypertrophy had segmental diastolic dysfunction. Thus impulse tissue doppler study is indicated to patients with hypertension and normal parameters of transmitral flow for assessment of longitudinal segmental diastolic left ventricular function.
