Related Experiment Video

Updated: Aug 30, 2026

Functional Assessment of Intestinal Tight Junction Barrier and Ion Permeability in Native Tissue by Ussing Chamber Technique
06:43

Functional Assessment of Intestinal Tight Junction Barrier and Ion Permeability in Native Tissue by Ussing Chamber Technique

Published on: May 26, 2021

A Peutz-Jeghers syndrome case with iron deficiency anemia and jejuno-jejunal invagination

Haci Mehmet Sökmen1, Ali Tüzün Ince, Cengiz Bölükbaş

  • 1Gastroenterology Clinic, Haydarpasa Numune Education and Training Hospital, Istanbul, Turkey. alince@superonline.com

The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology
|November 1, 2003
PubMed

Insights

Peutz-Jeghers syndrome, a rare genetic disorder, causes characteristic pigmentations and precancerous polyps. Early investigation of anemia and ileus is crucial for diagnosing this syndrome.

Area of Science:

  • Gastroenterology
  • Genetics
  • Dermatology

Background:

  • Peutz-Jeghers syndrome (PJS) is an autosomal dominant disorder.
  • It is characterized by mucocutaneous pigmentations and hamartomatous polyps in the gastrointestinal tract and other organs.
  • PJS is recognized as a precancerous condition, increasing cancer risk.

Observation:

  • A case report of a young patient presenting with gastrointestinal bleeding.
  • Endoscopic findings revealed multiple polyps in the stomach, jejunum, rectum, and terminal ileum.
  • The patient also exhibited mucocutaneous pigmentations on the lips, buccal mucosa, and nails.

Findings:

  • Jejunal polyps were identified as the cause of jejuno-jejunal intussusception and iron deficiency anemia.
  • Histopathological analysis confirmed hamartomatous polyps consistent with Peutz-Jeghers syndrome.
  • Dermatological consultation supported the diagnosis based on characteristic pigmentations.

Implications:

  • Highlights the importance of considering PJS in patients with unexplained anemia and ileus.
  • Emphasizes the diagnostic value of combined gastrointestinal and dermatological assessments.
  • Underscores the precancerous nature of PJS, necessitating vigilant monitoring and management.

Related Concept Videos

Intestinal Obstruction II: Pathophysiology01:07

Intestinal Obstruction II: Pathophysiology

Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...
Other Disorders of Digestive System01:30

Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
Intestinal Obstruction I: Introduction01:29

Intestinal Obstruction I: Introduction

Intestinal obstruction is a partial or complete blockage of the small or large intestine that disrupts the normal flow of intestinal contents through the lumen. This interruption impairs digestion, absorption, and fluid balance, and may lead to serious complications if not treated promptly.Mechanical ObstructionMechanical obstruction occurs when a physical blockage prevents intestinal contents from passing, arising from within the lumen or the bowel wall, or from external compression.Adhesions,...
Pyloric Obstruction01:11

Pyloric Obstruction

Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...