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Updated: Aug 30, 2026

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells
Published on: March 28, 2013
[Pharmacology of PPARalpha, PPARgamma and dual PPARalpha/gamma agonists in clinical development]
Daniel Duran-Sandoval1, Anne-Claire Thomas, Bernard Bailleul
1Inserm U.545, Département d'athérosclérose, Institut Pasteur de Lille, 1, rue du Professeur Calmette, 59019 Lille, France.
Abstract:
Cardiovascular diseases (CVD) remain the leading cause of mortality in the western societies. Several risk factors predispose to CVD including diabetes, obesity, insulin resistance, dyslipidemia and hypertension. Various pharmacological therapies have been developed to control the risk factors associated to CVD. Fibrates are able to correct dyslipidemia, therefore decreasing CVD risk. Thiazolidinediones (TZD) or glitazones by increasing insulin sensitivity decrease plasma glucose levels in diabetic patients. Both fibrates and TZD activate the peroxisome proliferator-activated receptors (PPARs), a family of nuclear receptors that play a central role in the control of lipid and glucose metabolism. In this review, we will discuss the mode of action of fibrates and TZD and we will present an overview on PPAR ligands under development.
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