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Updated: Aug 13, 2026

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
Published on: February 27, 2018
[Clinical and neuropsychological characteristics of Huntington's disease: a review]
J C Arango-Lasprilla1, J Iglesias-Dorado, F Lopera
1Grupo de Neurociencias, Universidad de Antioquia, Medellín, Colombia. lasprilla50@hotmail.com
Introduction:
Huntington's disease is a dominant autosomic neurodegenerative disorder. This article's objective is to provide an up-to-date description of the clinical and neuropsychological manifestations over the course of the disease.
Method:
According to clinical studies, the main characteristics of Huntington's disease include motor deficits, psychiatric problems and cognitive deficits. Many investigations have shown that a fronto-subcortical circuit dysfunction is responsible for these deficits. As the disease progresses, patients tend to have more cognitive difficulties which include attention/concentration problems, slowed cognitive processing, memory and language deficits, visuo-spatial problems and executive functioning difficulties.
Conclusion:
Studies with asymptomatic carriers of Huntington's disease have shown that cognitive deterioration may begin long before a clinical diagnosis of the disease is possible.
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