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Updated: Aug 30, 2026

Dissection of Single Skeletal Muscle Fibers for Immunofluorescent and Morphometric Analyses of Whole-Mount Neuromuscular Junctions
Published on: August 14, 2021
[The role of the electron microscope in the study of muscular diseases]
1Servicio de Patología, Hospital Universitario del Mar, Barcelona, España.
Aims:
Our study examines the most significant aspects of electron microscopy in primary and secondary myopathies from the point of view of the day-to-day activity of a general ultrastructural diagnosis laboratory.
Development:
We review cases of neuromuscular pathologies in which electron microscopy has contributed to greater accuracy in diagnosis or the understanding of the pathogenic process, and our own data were tested against the existing literature.
Conclusions:
As stated in several recent papers, our experience shows that electron microscopy is still a very important tool in the field of muscular diseases and can provide crucial diagnostic data, confirm the results obtained by other techniques or help settle the physiopathological foundations of many of these disorders.
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