Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Optimization of experimental antimitotic agents: classical and combinatorial methods.

Nathanael S Gray1

  • 1Genomics Institute, Novartis Research Foundation, 10675 John J. Hopkins Drive, San Diego, CA 92121, USA.

Progress in Cell Cycle Research
|November 5, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Type II CDK6 Degrader Enables Cellular Targeting beyond the Limits of Type II Inhibition.

Journal of the American Chemical Society·2026
Same author

Ratiometric transcriptional activation by protein degradation.

bioRxiv : the preprint server for biology·2026
Same author

The molecular basis for nuclear pore destruction by a proximity-inducing molecular glue.

Cell chemical biology·2026
Same author

Activating p53<sup>Y220C</sup> with a mutant-specific small molecule.

Nature communications·2026
Same author

Correction: Discovery and optimization of tau targeted protein degraders enabled by patient induced pluripotent stem cells-derived neuronal models of tauopathy.

Frontiers in cellular neuroscience·2026
Same author

Charged molecular glue discovery enabled by targeted degron display.

Nature chemical biology·2026

Natural products and combinatorial chemistry are key sources for discovering cell cycle compounds. These methods aid in identifying and optimizing novel drug leads for pharmacological applications.

Area of Science:

  • Pharmacology
  • Medicinal Chemistry
  • Drug Discovery

Background:

  • Compounds influencing cell cycle progression are vital for understanding biological functions and developing pharmaceutical agents.
  • Natural products from terrestrial and aquatic sources have historically yielded significant lead compounds and novel pharmacophores.
  • Traditional natural product drug discovery involves isolation, structural elucidation, scaled production, and structure-activity relationship studies.

Purpose of the Study:

  • To review the role of natural products and combinatorial chemistry in identifying and developing cell cycle-modulating compounds.
  • To highlight the methodologies employed in natural product-derived drug discovery.
  • To discuss the application of combinatorial chemistry in generating and optimizing molecular libraries for pharmacological screening.

Related Experiment Videos

Main Methods:

  • Isolation and structural elucidation of bioactive natural products.
  • Chemical and biosynthetic synthesis for compound production.
  • Application of combinatorial chemistry in diversity-generating and focused modes.
  • Iterative optimization using biochemical, cellular, and phenotypic assays.

Main Results:

  • Natural products represent a rich source of lead compounds and pharmacophores.
  • Combinatorial chemistry offers powerful tools for assembling and screening large molecular libraries.
  • Both natural product-derived and synthetic compounds require rigorous optimization via assays.

Conclusions:

  • The integration of natural product chemistry and combinatorial synthesis accelerates the discovery of novel therapeutic agents.
  • Efficient assay development is crucial for the iterative optimization of lead compounds.
  • Understanding cell cycle regulation through compound studies remains a critical area for pharmacological advancement.