Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The peptidyl-prolyl isomerase Pin1.

James D Joseph1, Elisabeth S Yeh, Katherine I Swenson

  • 1Department of Pharmacology and Cancer Biology, PO Box 3813, Duke University Medical Center, Durham, NC 27710, USA.

Progress in Cell Cycle Research
|November 5, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unconventional binding of calmodulin to CHK2 kinase inhibits catalytic activity.

The Biochemical journal·2025
Same author

Myeloid-specific CAMKK2 deficiency protects against diet-induced obesity and insulin resistance by rewiring metabolic gene expression and enhancing energy expenditure.

Molecular metabolism·2025
Same author

PSKH1 kinase activity is differentially modulated via allosteric binding of Ca<sup>2+</sup> sensor proteins.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Convergence on CaMK4: A Key Modulator of Autism-Associated Signaling Pathways in Neurons.

Biological psychiatry·2024
Same author

CaMKK2: bridging the gap between Ca2+ signaling and energy-sensing.

Essays in biochemistry·2024
Same author

CaMKK2 as an emerging treatment target for bipolar disorder.

Molecular psychiatry·2023

The prolyl-isomerase Pin1 enzyme regulates cell cycle progression and reentry from quiescence. This review explores Pin1

Area of Science:

  • Cell Biology
  • Biochemistry
  • Molecular Biology

Background:

  • The enzyme Pin1 (prolyl-isomerase) regulates cell cycle progression.
  • Pin1 interacts with key regulators of G1 and mitosis.
  • The precise cellular consequences of Pin1 binding are not well understood.

Purpose of the Study:

  • To review the role of Pin1 and its binding proteins in cell cycle regulation.
  • To explore the therapeutic potential of targeting Pin1.

Main Methods:

  • Literature review of studies on Pin1 function.
  • Analysis of Pin1's interactions with cell cycle regulators.
  • Discussion of Pin1 as a therapeutic target.

Main Results:

Related Experiment Videos

  • Pin1 is implicated in multiple aspects of cell cycle control.
  • Pin1's function is crucial for mitotic progression and cell cycle reentry.
  • Numerous Pin1-interacting proteins are key cell cycle regulators.

    • Conclusions:

    • Pin1 plays a critical role in cell cycle regulation.
    • Targeting Pin1 may offer therapeutic benefits for cell cycle-related disorders.