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Updated: Aug 1, 2026
08:38
Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay (PCA) in Living Cells
Published on: March 3, 2015
The peptidyl-prolyl isomerase Pin1
James D Joseph1, Elisabeth S Yeh, Katherine I Swenson
1Department of Pharmacology and Cancer Biology, PO Box 3813, Duke University Medical Center, Durham, NC 27710, USA.
Progress in Cell Cycle Research
|November 5, 2003
Summary
The prolyl-isomerase Pin1 enzyme regulates cell cycle progression and reentry from quiescence. This review explores Pin1
Area of Science:
- Cell Biology
- Biochemistry
- Molecular Biology
Background:
- The enzyme Pin1 (prolyl-isomerase) regulates cell cycle progression.
- Pin1 interacts with key regulators of G1 and mitosis.
- The precise cellular consequences of Pin1 binding are not well understood.
Purpose of the Study:
- To review the role of Pin1 and its binding proteins in cell cycle regulation.
- To explore the therapeutic potential of targeting Pin1.
Main Methods:
- Literature review of studies on Pin1 function.
- Analysis of Pin1's interactions with cell cycle regulators.
- Discussion of Pin1 as a therapeutic target.
Main Results:
- Pin1 is implicated in multiple aspects of cell cycle control.
- Pin1's function is crucial for mitotic progression and cell cycle reentry.
- Numerous Pin1-interacting proteins are key cell cycle regulators.
Conclusions:
- Pin1 plays a critical role in cell cycle regulation.
- Targeting Pin1 may offer therapeutic benefits for cell cycle-related disorders.
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