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Biosynthesis of modified peptidoglycan precursors by vancomycin-resistant Enterococcus faecium
N E Allen1, J N Hobbs, J M Richardson
1Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
FEMS Microbiology Letters
|November 11, 1992
Abstract:
In the presence of bacitracin, vancomycin-resistant Enterococcus faecium (vanA phenotype) accumulate UDP-N-acetylmuramyl(UDP-Mur-NAc)-tetrapeptide and a UDP-MurNAc-depsipentapeptide containing lactate substituted for the carboxy-terminal-D-alanine residue. In an in vitro peptidoglycan polymerization assay, the modified precursors function and confer resistance to vancomycin.