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Related Experiment Videos

Taking bisphosphonates during pregnancy.

Amy E French1, Nikolay Kaplan, Michael Lishner

  • 1Motherisk Team, Hospital for Sick Children in Toronto, Ont.

Canadian Family Physician Medecin De Famille Canadien
|November 5, 2003
PubMed
Summary
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Bisphosphonates, used for low bone mineral density, have limited safety data in human pregnancy. Animal studies indicate placental transfer and potential effects on fetus and mother, requiring careful risk-benefit assessment.

Area of Science:

  • Pharmacology
  • Obstetrics
  • Endocrinology

Background:

  • Bisphosphonates are commonly prescribed for low bone mineral density (BMD).
  • Concerns exist regarding the safety of bisphosphonate use in women of reproductive age.
  • Limited data is available on bisphosphonate effects during human pregnancy.

Purpose of the Study:

  • To evaluate the safety of bisphosphonate use during pregnancy.
  • To review existing literature on bisphosphonate exposure in pregnant patients.

Main Methods:

  • Literature review of case reports and animal studies.
  • Analysis of bisphosphonate placental transfer and potential fetal effects.

Main Results:

  • Only two case reports document bisphosphonate use in late pregnancy.

Related Experiment Videos

  • Animal studies demonstrate placental transfer of bisphosphonates.
  • Pharmacological effects are expected in both the fetus and mother.

    • Conclusions:

    • The effects of bisphosphonates on human pregnancy are largely unknown.
    • Careful consideration of risks versus benefits is essential when bisphosphonates are used during pregnancy.