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Sweet syndrome.

Edwin K Joe1

  • 1Ronald O. Perelman Department of Dermatology, New York University, USA.

Dermatology Online Journal
|November 5, 2003
PubMed
Summary

Sweet syndrome, a neutrophilic dermatosis, presents with fever and skin lesions. Systemic glucocorticoids are effective but may need prolonged use for recurrent cases.

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Area of Science:

  • Dermatology
  • Internal Medicine
  • Pathology

Background:

  • Sweet syndrome, also known as acute febrile neutrophilic dermatosis, is an inflammatory condition.
  • It is characterized by specific clinical and histopathological features.

Observation:

  • Patients typically present with fever, leukocytosis, and painful, red, well-defined skin lesions (papules and plaques).
  • Histological examination reveals dense neutrophil infiltration in the dermis and edema.

Findings:

  • Sweet syndrome can be idiopathic or associated with underlying malignant diseases.
  • Medications can also trigger the condition.
  • Histopathology confirms dense neutrophilic infiltrates and papillary dermal edema.

Implications:

  • While systemic glucocorticoids are generally effective for treatment, prolonged courses may be necessary to manage recurrent episodes.
  • Understanding the associations with malignancy and medication induction is crucial for comprehensive patient management.