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Olanzapine effects on auditory sensory gating in schizophrenia
Celso Arango1, Ann Summerfelt, Robert W Buchanan
1Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland, Baltimore, MD 21228, USA.
Objective:
New-generation antipsychotics have been proposed to normalize the P50 sensory gating index in patients with schizophrenia. In the context of a double-blind comparison of olanzapine and haloperidol, the authors examined the effect of olanzapine on P50 suppression.
Method:
P50 measurements were obtained at baseline while patients were being treated with fluphenazine and after 12 weeks of double-blind treatment with either olanzapine (N=12) or haloperidol (N=12).
Results:
There were no treatment group differences in P50 amplitude, latency, or sensory gating ratio.
Conclusions:
These results suggest that there is not a significant differential effect of olanzapine and haloperidol on the P50 sensory gating index in schizophrenia.