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[Foamy carcinoma of the prostate]
Roberto Llarena Ibarguren1, David Lecumberri Castaños, Jesús Padilla Nieva
1Servicio de Urología, Hospital de Cruces, Servicio Vasco de Slaud, Pz. de Cruces s/n 48903 Baracaldo, Vizcaya, España.
Objectives:
We report the first case of prostatic foamy gland carcinoma in the Spanish literature.
Methods:
Case of a 69-year-old male who consulted for PSA elevation up to 101 ng/ml. Transrectal ultrasound showed a heterogeneous gland with a hipoechogenic area in the right lobe and possible capsular disruption. Six ultrasound guided needle biopsies were performed. The samples from the right lobe were reported as Gleason 6 foamy cell prostatic adenocarcinoma.
Results:
Prostatic foamy cell carcinoma is a rare tumor, and so are its bibliographic references. Its cells lack of prominent nucleus and nucleoli. They show a plentiful and xanthomatous cytoplasm, with abundant intracytoplasmic pink secretions characteristically. It may be mistaken with low grade adenocarcinomas, and it is essential to differentiate it from the clear cell prostatic adenocarcinoma, prostatic adenosis, and even from benign prostatic hyperplasia. It usually has an intermediate grade, with a Gleason score greater than 4.