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Effect of growth on lung transfer factor and its components
K K Mahajan1, S K Mahajan, N Mishra
1Department of Physiology Medical College, Rohtak.
The Indian Journal of Chest Diseases & Allied Sciences
|April 1, 1992
Summary
Lung function tests, including carbon monoxide transfer factor (TLCO), diffusion capacity (Dm), and capillary blood volume (Vc), decline with age. Height positively correlates with TLCO and Dm, aiding in more accurate lung function predictions.
Area of Science:
- Pulmonary Physiology
- Respiratory Medicine
Background:
- Lung function parameters like TLCO, Dm, and Vc are crucial for assessing respiratory health.
- Understanding age and height influences on these parameters is vital for accurate clinical interpretation.
Purpose of the Study:
- To investigate the correlation between age and height with TLCO, Dm, and Vc in healthy males.
- To develop a prediction formula for TLCO incorporating both age and height.
Main Methods:
- Single breath technique was used to measure TLCO, Dm, and Vc.
- 120 healthy non-smoker males were included in the study.
- Statistical analysis was performed to determine correlations and develop prediction models.
Main Results:
- TLCO, Dm, and Vc all showed a negative correlation with increasing age.
- TLCO and Dm demonstrated a positive correlation with height, while Vc did not.
- A prediction formula combining age and height (TLCO120 = 3.8 + 21 H (m)-0.308 A) showed significant predictive value (R=0.6479, p < 0.001).
Conclusions:
- Age and height are significant factors influencing TLCO, Dm, and Vc in healthy males.
- Combined age and height provide a more accurate prediction of TLCO than either factor alone.
- The developed prediction formula can aid in the clinical assessment of lung function.