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Langerhans cell histiocytosis with periorbital cellulitis
Jaime Levy1, Tova Monos, Joseph Kapelushnik
1Department of Ophthalmology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel. levy_jaime@hotmail.com
Purpose:
To report a case of Langerhans cell histiocytosis presenting as periorbital cellulitis.
Design:
Interventional case report.
Methods:
A 3-year-old girl presented with periorbital swelling of the right upper lid laterally of two days' duration. A history of recent eye trauma was reported.
Results:
Computed tomography showed a soft tissue mass that eroded the frontozygomatic suture. The lesion was debulked through a lateral orbitotomy. Electron microscopy disclosed Birbeck granules. Immunohistochemistry stained positively for CD68 and CD1a antigenic determinants.
Conclusions:
Although rare, Langerhans cell histiocytosis can cause acute periorbital cellulitis in children. Trauma can induce an inflammatory response, allowing for earlier diagnosis of the orbital lesion.