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Updated: Aug 30, 2026
10:37
Development of Recombinant Proteins to Treat Chronic Pain
Published on: April 11, 2018
Development of HSV-mediated gene transfer for the treatment of chronic pain
Marina Mata1, Joseph Glorioso, David J Fink
1Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
Experimental Neurology
|November 5, 2003
Abstract:
Chronic pain is often difficult to treat effectively. We have exploited the high affinity of herpes simplex virus (HSV) for peripheral sensory neurons to create HSV-based vectors for the treatment of chronic pain. We have demonstrated that an HSV-based vector expressing proenkephalin reduces pain-related responses in rodent models of inflammatory pain, neuropathic pain, and pain resulting from cancer in bone. A human trial has been proposed.
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