Related Experiment Video
Updated: Aug 30, 2026

An Alternative to the Traditional Cold Pressor Test: The Cold Pressor Arm Wrap
Published on: January 16, 2014
Neither perceived job stress nor individual cardiovascular reactivity predict high blood pressure
Jean Pierre Fauvel1, Ignasse M'Pio, Pierre Quelin
1Département de Néphrologie et d'Hypertension artérielle, Hôpital E Herriot, 69437 Lyon, France. jean-pierre.fauvel@chu-lyon.fr
Insights
High job strain and cardiovascular reactivity to stress do not predict future high blood pressure (BP) in healthy adults. This 5-year study found no increased hypertension risk in individuals with high job strain or high BP stress reactivity.
Area of Science:
- Cardiovascular Health
- Occupational Health
- Hypertension Research
Background:
- Previous research indicated a link between high job strain and elevated diastolic blood pressure (DBP) during work hours.
- The influence of professional strain perception and cardiovascular reactivity on long-term blood pressure (BP) progression remained unclear.
Purpose of the Study:
- To evaluate the long-term impact of perceived professional strain and cardiovascular reactivity to mental stress on the development of hypertension.
- To assess whether high job strain (HS) or high BP stress reactivity (HR) are significant risk markers for future hypertension in healthy adults.
Main Methods:
- A cohort of 292 healthy adults was followed for 5 years to track progression to hypertension (defined by specific SBP or DBP increases).
- Subjects were categorized into high-strain (HS) and non-high-strain (NHS) groups, and high-reactivity (HR) and non-high-reactivity (NHR) groups for comparison.
- Kaplan-Meier survival analysis and end-of-follow-up 24-hour ambulatory BP measurements were utilized.
Main Results:
- Hypertension developed in 31.8% of the subjects over the 5-year follow-up period.
- Neither the high-strain group nor the high-reactivity group showed an increased incidence of hypertension compared to their respective control groups.
- End-of-study ambulatory BP levels were similar between the HS and NHS groups, and between the HR and NHR groups.
Conclusions:
- Perceived high job strain and high cardiovascular reactivity to mental stress do not appear to be major predictors of future high blood pressure in healthy young adults.
- Factors such as age, alcohol consumption, salt intake, BMI, and occupation did not confound these findings.
Abstract:
We have reported that high job strain was associated with a significantly higher diastolic blood pressure (DBP) of 4.5 mm Hg during the working hours, irrespective of BP reactivity to a stress test. We report the final results of the first 5-year follow-up study, which aimed to assess the respective influences of perception of professional strain and cardiovascular reactivity to a mental stress test on BP. A cohort of 292 healthy subjects (mean+/-SEM age, 38+/-1 years) was followed up for progression to hypertension outcome, which was defined as an increase in systolic blood pressure (SBP) or DBP >7 mm Hg or a DBP >95 mm Hg during follow-up. None of the subjects was lost to follow-up, and 209 subjects completed the study. The high-strain (HS) group, representing 20.9% of the subjects, was compared with the remaining subjects (non-high-strain [NHS]). Similarly, the subjects with the highest BP stress reactivity (HR; 20.9% of subjects) were compared with the remaining subjects (NHR). Progression to hypertension was reached by 93 subjects (31.8%). Kaplan-Meier survival estimates revealed that neither HS nor HR increased the incidence of progression to hypertension. End-of-follow-up 24-hour ambulatory BPs that were similar in HS and NHS (120+/-2 vs 120+/-1 mm Hg, respectively) and in HR and NHR (122+/-2 vs 120+/-1 mm Hg, respectively) confirmed our findings. Age, alcohol, salt diet, body mass index, and occupation did not interfere with our results. In conclusion, cardiovascular HR and HS do not appear to be major risk markers for future high BP in healthy, young adults.
Related Concept Videos
Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
Hypertension and Regulation of Blood Pressure
Factors affecting Blood pressure
Physiological Factors:
Blood Pressure
The average BP in an adult is typically around 120/80 mmHg (millimeters of mercury). In this measurement, the numerator (120) indicates the systolic pressure, which is the pressure in the arteries during the contraction of the heart's ventricles as blood is expelled. The denominator (80) represents the diastolic...
Blood Pressure
Antihypertensive Drugs: Action of β1 Blockers
