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Related Experiment Video

Updated: May 4, 2026

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Published on: May 6, 2020

The TRAIL to arthritis.

George C Tsokos¹, Maria Tsokos

¹Walter Reed Army Institute of Research, Building 503, Room 1A32, Robert Grand Road, Silver Spring, Maryland 20910, USA. gtsokos@usa.net

The Journal of Clinical Investigation

|November 5, 2003

Summary

Gene-modified dendritic cells expressing TNF-related apoptosis-inducing ligand (TRAIL) show promise in treating rheumatoid arthritis. This cell therapy approach successfully limited joint inflammation in a preclinical model, suggesting a new therapeutic avenue for rheumatic diseases.

Area of Science:

Immunology
Cell Therapy
Rheumatology

Background:

Rheumatoid arthritis involves synovial proliferation driven by antigen-specific lymphocytes.
Activated lymphocytes and synoviocytes in rheumatoid arthritis patients express receptors for TNF-related apoptosis-inducing ligand (TRAIL).

Discussion:

Dendritic cells (DCs) pulsed with collagen and engineered to express TRAIL were tested in a collagen-induced arthritis model.
This gene-modified cell therapy demonstrated a reduction in arthritis incidence and joint inflammation.

Key Insights:

TRAIL-expressing DCs can modulate the immune response in autoimmune joint inflammation.
Targeting TRAIL pathways offers a potential strategy for managing rheumatoid arthritis.

Outlook:

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Gene-modified cell therapy, specifically using TRAIL-expressing DCs, presents a promising therapeutic option for systemic rheumatic diseases.
Further research is warranted to explore the clinical applicability of this approach for rheumatoid arthritis treatment.