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Updated: May 4, 2026

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
Published on: May 6, 2020
The TRAIL to arthritis
George C Tsokos1, Maria Tsokos
1Walter Reed Army Institute of Research, Building 503, Room 1A32, Robert Grand Road, Silver Spring, Maryland 20910, USA. gtsokos@usa.net
Abstract:
Antigen-specific lymphocytes are involved in synovial proliferation within inflamed joints. Activated lymphocytes and synoviocytes from patients with rheumatoid arthritis express receptors that can bind TNF-related apoptosis-inducing ligand (TRAIL). A new study demonstrates that DCs pulsed with collagen and transduced with an adenovirus-based vector able to express TRAIL limit the incidence of arthritis in a model of collagen-induced arthritis and joint inflammation. These results suggest that gene-modified cell therapy represents a therapeutic option for systemic rheumatic diseases.
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