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Treatment of combined coronary and carotid artery disease
Joseph Huh1, Matthew J Wall, Ernesto R Soltero
1Division of Cardiothoracic Surgery, Houston Veterans Affairs Medical Center, Ben Taub General Hospital, Baylor College of Medicine, Houston, Texas 77401, USA. joseph.huh@med.va.gov
Insights
Treating combined coronary and carotid disease remains challenging. Staged procedures may offer lower stroke rates, but all surgical options carry risks for advanced atherosclerosis patients.
Area of Science:
- Cardiovascular Surgery
- Vascular Surgery
- Atherosclerosis Research
Background:
- Combined coronary and carotid disease presents a significant management challenge.
- Advanced atherosclerosis complicates treatment decisions for these patients.
Purpose of the Study:
- To evaluate current treatment indications and outcomes for combined coronary and carotid disease.
- To review surgical management strategies for patients with synchronous coronary and carotid stenosis.
Main Methods:
- Review of recent case series and meta-analyses on surgical interventions.
- Comparison of outcomes for staged versus combined synchronous surgical approaches.
Main Results:
- Approximately 8% of patients evaluated for coronary artery bypass grafting have significant carotid stenosis (>70%).
- Staged procedures showed a trend toward lower stroke rates compared to combined procedures.
- Overall morbidity and mortality risks were higher for combined disease compared to single-territory procedures.
Conclusions:
- Treatment indications and surgical options for combined coronary and carotid disease remain controversial.
- Advocacy for treating the symptomatic territory first using staged procedures.
- Combined procedures are reserved for patients with critical stenosis or symptoms in both territories.
Purpose Of Review:
The purpose of this review is to evaluate the current indications and results of treatment of combined coronary and carotid disease. Synchronous carotid stenosis in patients with coronary artery disease poses a management challenge in patients with advanced atherosclerosis.
Recent Findings:
Recent case series continue to demonstrate concomitant coronary and carotid disease with significant carotid stenosis greater than 70% in approximately 8% of patients evaluated for coronary artery bypass grafting. Surgical management options include staged operations addressing the carotid stenosis first, reverse staged operations addressing the coronary disease first, and combined synchronous operations addressing both territories during the same anesthetic. Recent reports demonstrate safety and acceptable risks with each operative approach. Lower trends in stroke rates were noted following staged procedures when compared with combined procedures. However, several metaanalyses showed no significant difference in rates of combined morbidity and mortality for all three strategies. Total morbidity and mortality risks for combined disease tended to be higher than for isolated coronary artery bypass grafting or carotid endarterectomy procedures performed for disease in a single vascular territory.
Summary:
Despite a large volume of data present in the literature, the treatment indications and surgical options remain controversial. We currently advocate treatment of symptomatic territory first in favor of staged procedures and reserve combined procedures for patients with critical stenosis or symptoms in both territories.
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