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Updated: Aug 30, 2026

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
Published on: October 4, 2021
Acute akinesia or akinetic crisis in Parkinson's disease
A Thomas1, D Iacono, A L Luciano
1Department of Neurophysiopathology, Movement Disorder Center, Department of Oncology and Neuroscience, University G. D'Annunzio, Chieti-Pescara, Italy.
Abstract:
In 22 patients with idiopathic Parkinson's disease we observed a sudden worsening of motor symptoms and severe akinesia during hospitalization because of infectious diseases, bone fractures, surgery for gastrointestinal tract diseases, and iatrogenic causes. Of these patients, 12 recovered completely, 6 had a partial recovery, and 4 died. Treatments included subcutaneous apomorphine/lisuride infusion and dantreolene (with a creatine phosphokinase level higher than 200 IU). In all patients a definite refractoriness to therapy was shown with a transient lack of response to apomorphine.
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