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Related Experiment Videos

Microtubules and growth cone function.

Phillip R Gordon-Weeks1

  • 1MRC Centre for Developmental Neurobiology, King's College London, London SE1 1UL, England. phillip.gordon-week@kcl.ac.uk

Journal of Neurobiology
|November 5, 2003
PubMed
Summary
This summary is machine-generated.

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The neuronal cytoskeleton, including actin and microtubules, guides growing axons. Recent studies reveal microtubule roles and interactions with actin in growth cone pathfinding and turning.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Developmental Biology

Background:

  • The neuronal cytoskeleton is crucial for neurite growth and axon pathfinding.
  • Growth cone guidance cues activate intracellular signaling pathways converging on the cytoskeleton.
  • Research has primarily focused on the actin cytoskeleton's role in growth cone motility.

Purpose of the Study:

  • To review recent findings on microtubule function in growth cones.
  • To explore how guidance cues regulate microtubule behavior.
  • To elucidate the interaction between actin and microtubules in growth cone pathfinding.

Main Methods:

  • Review of recent experimental data on growth cone cytoskeleton dynamics.
  • Analysis of intracellular signaling pathways activated by guidance cues.

Related Experiment Videos

  • Investigation of microtubule-actin interactions.

    • Main Results:

    • Microtubules play a significant role in growth cone pathfinding, beyond actin's established functions.
    • Guidance cues regulate microtubule dynamics via cell membrane receptors and intracellular signaling.
    • A critical interaction between actin filaments and microtubules is essential for growth cone turning.

    Conclusions:

    • Microtubules are integral to growth cone pathfinding and are regulated by external cues.
    • The interplay between microtubule and actin cytoskeletons is fundamental for directed axon growth.
    • Further research into these cytoskeletal interactions will illuminate mechanisms of neural development.