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Related Experiment Videos

Premixed calcium-phosphate cement pastes.

Shozo Takagi1, Laurence C Chow, Satoshi Hirayama

  • 1American Dental Association Foundation, Paffenbarger Research Center, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA. shozo.takagi@nist.gov

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
|November 5, 2003
PubMed
Summary

New glycerol-containing calcium-phosphate cement (CPC) pastes offer improved stability and washout resistance for bone defect repair. These premixed CPCs harden upon contact with bodily fluids, forming hydroxyapatite (HA).

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Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Materials Chemistry

Background:

  • Self-hardening calcium-phosphate cements (CPCs) are effective for bone defect repair.
  • Conventional CPCs harden rapidly (approx. 10 min) using phosphate solutions, forming hydroxyapatite (HA).
  • A need exists for CPCs with extended working times and improved handling characteristics.

Purpose of the Study:

  • To investigate the properties of novel water-free, glycerol-containing CPC pastes.
  • To evaluate the stability, hardening behavior, and mechanical strength of these premixed CPCs.
  • To assess the influence of glycerol-tissue fluid exchange on CPC performance.

Main Methods:

  • Premixed CPC pastes were formulated using glycerol-based liquids and various CPC powders.

Related Experiment Videos

  • Powder compositions included Ca(4)(PO(4))(2)O/CaHPO(4), α-Ca(3)(PO(4))(2)/CaCO(3), and CaHPO(4)/Ca(OH)(2).
  • An in vitro model simulated glycerol-tissue fluid exchange at 37°C to measure hardening time and diametral tensile strength (1-d and 7-d).

    • Main Results:

    • All tested CPC pastes exhibited excellent washout resistance.
    • Pastes remained intact and hardened in physiologic-like solution (PLS), forming HA.
    • The concentration of Na(2)HPO(4) significantly impacted strength and hardening time (p < 0.05), while hydroxypropyl methylcellulose (HMC) did not.

    Conclusions:

    • Glycerol-containing CPC pastes demonstrate good stability and washout resistance.
    • These premixed CPCs harden upon contact with physiologic-like fluids, forming HA.
    • The formulation offers potential for improved handling and preparation of CPCs for bone regeneration.