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A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
Published on: July 6, 2017
Carcinoid tumour of the appendix
A C Goede1, M E Caplin, M C Winslet
1University Department of Surgery, Royal Free Hospital and University College London Medical School, London, UK. agoede@rfc.ucl.ac.uk
The British Journal of Surgery
|November 5, 2003
Summary
Appendiceal carcinoid tumors are rare, and management after appendectomy is debated. Right hemicolectomy is indicated for tumors larger than 2 cm or with high-grade malignancy, mesoappendiceal invasion, or positive margins.
Area of Science:
- Gastroenterology
- Surgical Oncology
Background:
- Appendiceal carcinoid tumors occur in 0.3-0.9% of appendectomies.
- Management, particularly right hemicolectomy for tumors <2 cm, remains controversial.
Purpose of the Study:
- To review appendiceal carcinoid tumor behavior.
- To establish indications for right hemicolectomy.
Main Methods:
- Literature review on appendiceal carcinoid tumor behavior.
- Analysis of factors influencing metastatic disease risk.
Main Results:
- Metastatic disease is rare but more common in tumors >2 cm.
- Risk-benefit of right hemicolectomy requires further definition.
Conclusions:
- Clear indications for right hemicolectomy are limited.
- Indications include tumors >2 cm, high-grade malignancy, mesoappendiceal invasion, positive margins, and goblet cell adenocarcinoids.
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